Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous- violaceous. Tumid lupus erythematosus (TLE), also known as lupus erythematosus tumidus, is a highly photosensitive form of cutaneous lupus erythematosus (cutaneous. MalaCards based summary: Lupus Erythematosus Tumidus, also known as intermittent cutaneous lupus, is related to lupus erythematosus and discoid lupus .

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Retrieved from ” https: Laboratory abnormalities or substantial ocular toxic effects caused by antimalarials did not occur in any of the patients with LET. Since its tumjdus description inLET has been documented rarely in the literature, and its clinical importance has not been fully appreciated. Right upper arm with blanching inflamed plaques with raised borders. Lpuus are the specific features of cutaneous lupus erythematosus? Features of neonatal cutaneous LE may include:.

Report of 40 cases. However, in our opinion, there is no doubt about LET being a separate entity that has been neglected in the literature since first being described in Bull Soc Fr Dermatol Syphiligr. Consent for publication was obtained by our patient. Discussion LET is a photosensitive skin disease that is characterized by succulent, edematous, non-scarring plaques. Hawaii J Med Public Health. Abstract Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous-violaceous lesions that leave no scars after regression.

Create a personal account to register for email alerts with links to free full-text articles. In our patient, despite already being treated with hydroxychloroquine sulfate, mycophenolate mofetil, and tacrolimus for SLE and lupus nephritis, she developed lesions of LET. Histopathologically, the epidermis is generally spared or presents discrete focal vacuolar degeneration of the basal membrane, associated with a perivascular lymphohistiocytic lesion infiltrated in the papillary and reticular dermis and interstitial mucin deposition.


Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous-violaceous lesions that leave no scars after regression. Get free access to newly published articles. None of the 40 patients had a history of drug-induced LET in our study after up to 15 tumiduw of follow-up.

Erythematous infiltrated lesion in the thorax with central clearing. Increased dermal mucin was noted and confirmed by lulus colloid iron stain Figure 4. If you have any concerns with your skin or its treatment, see a dermatologist for advice. This page was last edited on 1 Julyat Copyright American Medical Association.

British Journal of Dermatology, Direct immunofluorescence tests may show positive antibody deposition along the basement membrane lupus band test. Lupus erythematosus tumidus, a neglected subset of cutaneous lupus erythematosus.

Privacy Policy Terms of Use. LE nearly always affects the skin to some degree. Verh Dtsch Ges Pathol. Young women are most often affected, and there is no restriction to race or age. LE is classified lu;us autoimmuneas it is associated with pathogenic antibodies directed against components of cell nuclei in various tissues.

J Am Acad Dermatol. Course of the disease and therapy. Characteristic skin lesions of lupus erythematosus tumidus. One of the patients had had LET for more than 30 years at presentation in our clinic; however, most patients had been affected for less than 6 years Table 1.


Tumid lupus erythematosus

Histological evaluation of luus lesions is necessary to confirm the diagnosis of LET, and, therefore, it represents one of the major criteria of this disease Table 3.

Med Cutan Ibero Lat Am. Despite being first described inthere are few case reports in the current literature describing this disease and even fewer that discuss treatment. What if there is a fourth recurrence? Twenty-two patients achieved complete or almost complete remission.

Chronic cutaneous lupus erythematosus CCLE has polymorphous presentations that may occasionally mimic other clinical conditions, causing diagnostic difficulties. Lupus erythematosus tumidus LET is a photosensitive skin disease characterized by succulent, edematous, and non-scarring plaques. Succulent, edematous plaques on the cheek left and forehead right of 2 patients.

As previously described, 15 results of direct immunfluorescence in specimens from patients with LET have mostly been negative at tumidua dermoepidermal junction or around the papillary and reticular dermal blood vessels.

Selection and preparation of skin specimens.

Cutaneous lupus erythematosus | DermNet NZ

If lesions recur for a luus time, it may be reasonable to increase our patient’s hydroxychloroquine sulfate therapy to 6—6. Sign in to access your subscriptions Sign in to your personal account.

Best Pract Res Clin Rheumatol. Purchase access Subscribe to the journal. Treatment for cutaneous and systemic LE may include:. Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosus.