PDF | Libidibia ferrea, popularly known as “pau ferro” or “jucá”, is an important medicinal plant employed for the treatment of various ailments in. Genus: Libidibia (formerly known as Ceasalpinia). species: ferrea. Family: Fabaceae. Common Name: Leopard tree, Brazilian Ironwood. Description. Unarmed tree, to 15 m. Bark very distinctive, smooth, grey, pealing to reveal paler patches. Leaves 2-pinnate; pinnae in pairs, each with

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Antitumor activity and antioxidant status of Caesalpinia bonducella against ehrlich ascites carcinoma in Swiss albino mice. Our results corroborate theirs, both showing significant reduction in nociception in treated groups.

In order to identify the possible analgesic effect of the LF aqueous seed extract, an abdominal writhing test was performed. Results and Discussion Natural products, known as secondary metabolites of plants or animals, continue to be an important segment of research into new drugs. It is likely that CE and F80 show their anti-inflammatory activity through the downregulation of NO production and reduction in leukocyte migration. The LPLF caused an increase in the latency time of the animals in all analyzed periods at 2.

Anatomical and histochemical descriptions were made with the aid of image analysis software Axiovision using an Axioplan Zeiss microscope. The negative control group received only saline, and the standard group positive received MTX as referential antitumor drug. It is possible that the linoleic acid might be acting through this mechanism [ 31 ].

Since CE and F80 were confirmed to have anti-inflammatory activity in carrageenan-induced peritonitis Figure 2 and Table 1their analgesic activity was examined. View at Google Ferreaa R.

Increased sampling reveals new insights and more genera than expected”. The authors declare that there is no conflict of interests regarding the publication of this paper. It is found along all tropical regions in Brazil but manly in the north and northeast areas [ 1 ].


Previous Melbourne Royal Botanic Gardens. Acetic acid-induced abdominal constriction, formalin-induced pain, and hot-plate test in mice were employed in the study.

Studies were carried out in male mice, six animals per group, aiming to investigate the in vivo antitumor activity of CE and F80 against sarcoma This site uses Akismet to reduce spam. There are different routes to evaluate nociception; libidbiia, the assay using intraperitoneally acetic acid was the chosen approach.

CE and F80 inhibited writhing regarding antinociceptive activity acetic acid-induced writhing response in mice. View at Google Scholar C. Libidibia ferreaformerly Caesalpinia ferrea[1] [2] and commonly known as Pau FerroBrazilian ironwoodMoradoor leopard tree[3] is a tree found libiddibia Brazil and Bolivia.

Libidibia ferrea

View at Google Scholar M. Indexed in Science Citation Index Expanded.

In summary, Libidibia ferrea seeds store linoleic, oleic, linolenic, palmitoleic, palmitic, stearic, and capric fatty acids, mainly in the cotyledon, macrosclereids, and thicker cell walls. In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus.

Experimental results have indicated that substance P and bradykinin participate in this early phase [ 32 ]. According to Kelly et al. Materials and Methods 2. Further pharmacological and chemical studies are necessary to confirm and to better characterize the exact mechanism s responsible for the antinociceptive action. Iron referring to hard wood. The allergen is R -3,4-dimethoxydalbergion, a strong skin sensitizer.

Acute and subacute toxicity studies of Aegle marmelos Corr.

Libidibia ferrea

Four hours later, animals were sacrificed by cervical dislocation, and immediately the abdomen was opened [ 15 ]. Biochimica et Biophysica Acta. Fetrea the carrageenan model is typically associated with activation of the cyclooxygenase pathway and is sensitive to glucocorticoids and prostaglandin synthesis antagonists, ferrrea early phase of the carrageenan response is due to the release of serotonin and histamine [ 26 ].


Please review our privacy policy. Illustrated Cyclopedia of Brazilian Medicinal Plants. In summary, Libidibia ferrea has a large amount of lipids storage sites in different seed parts containing different lipids unsaturated, neutral, and acid.

Libidibia ferrea – Wikipedia

Coelho1 M. In conclusion, CE and F80 have no significant cytotoxic or antitumor activities in cell lines showing low toxicity and no action against tumors in vivo.

After these analyses, LPLF was used in subsequent ferrda tests hot-plate and formalin-induced lickingwhich demonstrated a cerrea analgesic effect in both tests, confirming that the antinociceptive effect in the seeds extract could be attributed to at least one of LPLF components.

CE did not show significant cytotoxic activity for either cell line.

Inhibition percentage was calculated through the decrease of total number of writhings in the treated groups against the libidibiq group. The response to an i. Modulating leukocyte recruitment in inflammation.

The animals were pretreated i. Dipyrone potentiates morphine-induced antinociception in dipyrone-treated and morphine-tolerant rats. Pauferrol A, a novel chalcone trimer with a cyclobutane ring from Libidiibia ferrea mart exhibiting DNA topoisomerase II inhibition and apoptosis-inducing activity. It can also be used as a pioneer plant for liidibia native woodland because of its tolerance to sun, reasonably fast growing and nitrogen fixing ability.

By using this site, you agree to the Terms of Use and Privacy Policy. GC with flame ion detection FID. Shade, Ornamental park or street tree, although consideration should be made to plant away from underground pipes or sewers as roots pibidibia invade.

Table 2 Antinociceptive effect of standard drugs piroxicam and dipyroneCE, and F80 on acetic acid-induced writhing response test in mice. Propagation from older wood cuttings and dipping into a plant hormone.