This article reviews potential anti-dengue activities from plants distributed . In the Philippines, Euphorbia hirta, known locally as “tawa–tawa”. Management of thrombocytopenia and flu-like symptoms in dengue patients with herbal water of Euphorbia hirta. Mir M, Khurshid R, Aftab R. BACKGROUND. PDF | Euphorbia hirta commonly known as Tawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue.

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Dengue fever in Malaysia In Malaysia, with a population of Management involves supportive care. Summary of studies conducted on antidengue activity of Euphorbia hirta. For each of the 3 indigenous areas surveyed, at least 20 respondents aged were randomly selected. It is a species of oak native to Morocco, Portugal and Spain.

Mir et al had similar observations in their study among confirmed dengue cases in Lahore, Pakistan. Inhibitory effect of essential oils obtained from plants grown in Colombia on yellow fever virus replication in vitro.

Interviews with teachers in these areas reveal that the study of medicinal plants on the scientific and anecdotal points of view has been incorporated in elementary and high school science curriculums.

Map of the Philippines showing the province of Pangasinan and the three surveyed areas. Nil, Conflict of Interest: Further purification of ethyl acetate fractions of the plant revealed 9 compounds which may exert an antidengue effect individually or synergistically [ 24 ].


Platelet augmentation activity of selected Philippine plants. In the endosome, the virus penetrates deep into the cell until the endosome membrane acquires a negative charge, which allows it to fuse with cengue endosomal membrane to open a port for release of genetic material.

Journal of Tropical Medicine

It should be noted that the symptoms of dengue enumerated in Table 5 may be symptoms of other diseases as well, such as bacterial and viral infections and certain inflammatory conditions. Many plant extracts in different solvents have been reported to exhibit activity against a vector of dengue fever, Ae. Therefore, any extensive study on the potential of plants with isolated active compounds that have shown anti-dengue activity should go through additional in vitro and in vivo animal testing followed by toxicity and clinical tests.

The sampling and survey were conducted from January 15 to March 15, One additional article was identified by manually searching the reference lists and forward citations of included papers. Euphorba is an erect, fast-growing and unbranched tree or shrub indigenous to Central America and cultivated in Mexico and most tropical countries for its edible fruits.

Boesenbergia rotunda Boesenbergia rotunda belongs to family Zingiberaceae. Each specimen of E. Support Center Support Center. Int J Res Stud Psychol.

View at Google Scholar A. In rural areas, such as the three indigenous communities surveyed in this study, limited access to modern health care facilities limits early detection of dengue which is important to avoid long-term complications.


Further, the effect ehphorbia E. The IC 50 of carragenans isolated from M. In recent years, the current dengue epidemic has become a focus of international public health awareness.

Antiviral actions of flavonoid-derived compounds on Dengue virus type Euphorbiaceae in ethanol-induced thrombocytopenic rat models. For instance, 3 respondents in Mt. However, a carboxy-reduced fucoidan in which euphoorbia acid was converted to glucose attenuated the inhibitory activity on DENV2 infection.

It is an aquatic plant known as eelgrass and is native to North America and Eurasia.

Potential Use of Euphorbia hirta for Dengue: A Systematic Review of Scientific Evidence

There are limited ethnobotanical studies conducted in Luzon, the largest island in the Philippines. In addition, it was assumed that the anti-inflammatory potential of flavonoids may have contributed to the alleviation of flu-like symptoms in dengue patients following the treatment with E.

Within this period, 17 and 15 cases of dengue were reported in the municipalities of Balungao and San Fabian i. Additional articles were obtained manually using the reference lists of included articles. Platelet-increasing effects of Euphorbia hirta Linn. About Health Dengue fever medicine.