BYETTA PACKAGE INSERT PDF
Patient Information Leaflet. Package leaflet: Information for the patient. Byetta 5 micrograms solution for injection in pre-filled pen. Byetta 10 micrograms solution . Learn about BYETTA, the BYETTA Pen. in patients with prior severe hypersensitivity reactions to exenatide or to any of the product components. PRODUCT MONOGRAPH. BYETTA® exenatide injection. µg/mL. mL prefilled pen (60 doses of 5 µg/dose) and. mL prefilled pen.
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Tolbutamide has usually been considered compatible with breast-feeding. Adequate blood glucose monitoring should be continued and followed. Treatment with mecasermin has been shown to improve insulin sensitivity and to improve glycemic control in patients with either Type 1 or Type 2 diabetes mellitus when used alone or in conjunction with insulins.
Thin or smaller individuals can use a 45 degree angle to avoid intramuscular injection. Postmarketing reports of serious hypersensitivity reactions eg anaphylaxis and angioedema. Major Careful monitoring of blood glucose is recommended when chloroquine and antidiabetic agents, including the incretin mimetics, are coadministered.
Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine: Lightly pinch a fold of skin; insert the needle; release the skin; inject at a 90 degree angle.
If a dose is missed and the next regularly scheduled pavkage is 1 or 2 days later, the patient should not administer the missed dose, instead they should wait until the next regularly scheduled dose. Minor Monitor blood glucose concentrations for needed antidiabetic agent dosage adjustments in diabetic patients whenever a change in either nicotine intake or smoking status occurs.
Byetta (exenatide) dose, indications, adverse effects, interactions from
The main risk factors for impaired glucose tolerance due to corticosteroids are the dose of steroid and duration of treatment. After injection, properly dispose of the pen and needles. The following pen needles have been tested and are considered to be compatible with the Byetta pre-filled pen: Hypoglycemia should be monitored for by the patient and clinician when exenatide treatment is initiated and continued. Moderate Animal data indicate that monoamine oxidase inhibitors MAOIs may stimulate insulin secretion.
No dosage adjustment needed. Exenatide has a short plasma half-life insetr a high molecular weight. Patients may develop antibodies to exenatide.
Since clonidine inhibits the release of catecholamines, clonidine may hide symptoms of hypoglycemia such as tremor, tachycardia, and blood pressure packags. In some patients, hypoglycemia can be prolonged. It is unknown whether extended-release exenatide causes thyroid C-cell tumors, including medullary thyroid carcinoma MTCin humans. Minor Diazoxide, when administered intravenously or orally, produces a prompt dose-related increase in blood glucose level, due primarily to an inhibition of insulin release from the pancreas, and also to an extrapancreatic effect.
Patients should also self-monitor blood glucose levels. Dosage adjustments of warfarin may be necessary. Monitor blood glucose and glycemic control and adjust therapy as clinically indicated. Ethanol inhibits gluconeogenesis, which can contribute to or increase the risk for hypoglycemia.
Official BYETTA® (exenatide) injection Healthcare Professional Website
Endogenous human incretins, such as glucagon-like peptide-1 GLP-1 enhance insulin secretion after release from the gut into the systemic circulation. Bismuth Subsalicylate; Metronidazole; Tetracycline: Hypoglycemia, sometimes resulting in coma, can occur.
Even if the disposable needle is changed, sharing may result in transmission of hepatitis viruses, HIV, or other blood-borne pathogens. A reduction in dose of oral hypoglycemic medications may be required in some patients taking orlistat.
Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate: Also, adrenergic medications may decrease glucose uptake by muscle cells. Indert mean apparent volume of distribution of exenatide following subcutaneous administration of a single dose of exenatide is Additionally, acetaminophen Tmax was delayed from 0.
Exenatide extended-release injection suspension Bydureon, Bydureon BCise: Some incretin mimetics make specific recommendations to reduce the risk for interaction. Moderate Metoclopramide can enhance gastric emptying in patients with diabetes. When possible, it may be prudent to avoid exenatide until data in human pregnancy is available.
A statistically significant increase in malignant thyroid C-cell tumors was observed in female rats receiving extended-release exenatide at times clinical exposure compared to controls. Initially, 5 mcg subcutaneously twice daily given within the minute period before the morning and evening meal.
Close monitoring of blood glucose is recommended. Hyperglycemia has been reported as well and is possibly due to beta-2 receptor blockade in the beta cells of the pancreas.
The manufacturer of exenatide provides an insulin glargine dose titration algorithm to aide clinicians when using exenatide with insulin glargine; consult product labels. Patients at risk include those with compromised renal function, those fasting for prolonged periods, those that are malnourished, and those receiving high or excessive doses of sulfonamides. Patient and family education regarding hypoglycemia management is crucial; the patient and patient’s family should be instructed on how to recognize and manage the symptoms of hypoglycemia.
Symptomatic hypoglycemia, which may be severe, has been reported in type 1 diabetic patients. The potential of extended-release exenatide to induce C-cell tumors in mice has not been evaluated. Pen-sharing poses a risk for transmission of blood-borne pathogens, even if the needle is changed.
In Type 2 diabetes patients with partially intact insulin reserves, octreotide administration may result in decreases in plasma insulin levels and hyperglycemia.
Call your healthcare provider right away if you have nausea, vomiting, or diarrhea that will not go away, or if you cannot take liquids by mouth.
Constituents in garlic might have some antidiabetic activity, and may increase serum insulin levels and increase glycogen storage in packkage liver. The mechanism of the interaction is not known although it may be due to delayed gastric emptyingnor is the clinical significance of this potential interaction. Exenatide does not impair the normal glucagon response to hypoglycemia.
Patients with diabetes mellitus taking incretin mimetics should be monitored closely for hypoglycemia if consuming green tea. Concurrent treatment with prandial insulin has not been studied and cannot be recommended.
Monitor for loss of glycemic control when pseudoephedrine, phenylephrine, and other sympathomimetics are administered to patients taking antidiabetic agents.