Amitraz intake is rarely lethal and management is symptomatic. Lack of a specific antidote and management protocols for amitraz intoxication, leave only the. Amitraz poisoning is fairly uncommon in humans and occurs via oral, dermal or inhalational routes. Only a limited number of case reports of. Other frequently occurring symptoms after massive amitraz intoxication are CNS depression, respiratory depression, miosis.

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Levels of blood urea, creatinine, and sodium and potassium usually do not change in this poisoning, which is consistent with our observation.

The patient was managed with symptomatic treatment, her condition pojsoning improving after 12 hours and she was discharged in good health over next 36 hours. Arch Med Sci ; 7: Atropine is a first line therapy for the bradycardia that results from vagal stimulation and atrioventricular blocks, but not for those related to other mechanisms The kalyoncu and colleagues reported respiratory alkalosis in two cases, respiratory acidosis in three cases, and metabolic poiaoning in five cases None, Conflict of Interest: An unusual poisoning with the unusual pesticide amitraz.

Suicidal attempt; Symptomatic treatment Citation: We consulted with the neurologist, and everything seemed normal.

Medline and Embase databases were amitfaz systematically since inception to January for case reports, case series and original articles using the following search terms: However, most studies reported that using atropine for those with both miosis and bradycardia resolved the problem 8 – Extrapolation from safety data to management of poisoning with reference to amitraz a formamidine pesticide and xylene.


Molecular and functional characterization of an octopamine receptor from honeybee Apis mellifera brain.

Middle East J Fam Med ; 4: Indian J Pediatr ; Poioning plants the biotransformation of amitraz proceeds very rapidly. Basic toxicological approach has been effective in two poisoned patients with amitraz ingestion: Amitraz-induced glucose intolerance in rats: We did not observe any changes in her ECG. Recovery usually occurs within hours and the patients are discharged without any organ dysfunction. Like other formamidines amitraz inhibits the synthesis of prostaglandin E2 from arachidonic acid by bovine seminal vesicle microsomes.

CASE REPORT – Amitraz: An unusual poisoning – Anaesthesia, Pain & Intensive Care

Kinetics and Mechanism of Amitraz Hydrolysis. Toxicity and kinetics of amitraz in dogs. Journal of Agricultural and Food Chemistry. Eur J Pediatr ; Amitraz depresses cardiovascular responses to bilateral carotid occlusion.

Amitraz – Wikipedia

Amitraz poisoning carried a good poisonjng with only six reported deaths case fatality rate, 1. Frequencies of various clinical features described in amitraz poisoning Click here to view. Toxic effects include numerous signs and symptoms varying from nausea, vomiting, bradycardia, hypotension or hypertension, hypothermia, hyperglycemia, polyuria, decreased gastrointestinal motility and intestinal distension, miosis, CNS depression with drowsiness, respiratory depression, convulsions and coma.


Poisoning from amitraz is underrecognized even in areas where it is widely available.

Observation of miosis early in the intoxication followed amigraz progression to mydriasis suggests that the presynaptic effect is dominant in the early phase and the postsynaptic effect in the late phase of the intoxication. Stimulating these receptors is in great extent the reason for the neurotoxic and preconvulsant effects of amitraz.

Amitraz Poisoning Treatment: Still Supportive?

It has shown to have reversible toxic effects on both animals and human beings which are rarely lethal or long lasting beyond 48 hours. Vet Hum Toxicol poisonihg Find articles by Ali Mohammad Sabzghabaee. By using this site, you agree to the Terms of Use and Privacy Policy.

It was first synthesized by the Boots Co. Aimtraz Toxicol ; Although activated charcoal and cathartic effects have not been evaluated, these are still included in the treatment protocol of these patients.

CASE REPORT – Amitraz: An unusual poisoning

Time to appearance of the initial symptoms ranged from 5 to minutes. As no specific antidote for amitraz poisoning exists, symptomatic treatment, comprising of intravenous atropine mg every hourantacids, multivitamins, diuretics and maintenance fluids, was instituted.

Chemical aspects of a new group of pesticides.