Amitraz intake is rarely lethal and management is symptomatic. Lack of a specific antidote and management protocols for amitraz intoxication, leave only the. Amitraz poisoning is fairly uncommon in humans and occurs via oral, dermal or inhalational routes. Only a limited number of case reports of. Other frequently occurring symptoms after massive amitraz intoxication are CNS depression, respiratory depression, miosis.

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Medline and Embase databases were searched systematically since inception to January for case reports, case series and original articles using the following search terms: Data were extracted from wmitraz charts retrospectively, and included age, gender, mode of poisoning, initial symptoms, time to appearance of initial symptoms, clinical amitrax laboratory findings, management, and prognosis.

Journal of Agricultural and Food Chemistry. In rats the metabolic pathway figure 3 has been examined after oral administration of 14C-labelled amitraz, which was found to be effectively metabolized, degraded and excreted to four of the metabolites in urine and six in faeces. In Turkey during41 cases of deadly amitraz intoxications have been detected.

Acute amitraz poisoning in adults: clinical features, laboratory findings, and management.

Hyperglycemia, commonly associated with amitraz poisoning, was not observed in our case, probably due to lower levels of poison absorption. Amitraz is a triazapentadiene compound, a member of the amidine chemical family 1. In plants the biotransformation of amitraz proceeds very rapidly.


Acute amitraz intoxication in human. Teratogenic effects of amitraz, 2,4-dimethylaniline, and paraquat on developing frog Xenopus embryos. Hsu and colleagues claimed that atropine increased heart rate and prevented amitraz induced bradycardia in animals By using this site, you agree to the Terms of Use and Privacy Policy.

Iran J Pharm Res. Arch Environ Contam Toxicol ; Forensic Toxicol ; J Vet Pharmacol Ther ; Management of amitraz poisoning is still considered to be supportive and symptomatic.

This effect could be antagonized by alpha2-adrenergic blocking agents, but administration of other antagonists did not reduce the depressant effect on the gastrointestinal transit.

Amitraz, an underrecognized poison: A systematic review Dhooria S, Agarwal R – Indian J Med Res

Levels of blood urea, creatinine, and sodium and potassium usually do not change in this poisoning, which is consistent with our observation. Followed by hydrolysis to 2,4-dimethylaniline, which also benefits from a basic pH.

In conclusion, basic approach to a patient with amitraz poisoning consists of initial stabilization, reducing absorption, and aamitraz elimination of the toxin.

S Afr Med J ; Acute amitraz intoxication in human. These can be traced back to the amitarz of action, which lead to a wide field of effects, including direct lethalityexcitant-repellant behavioral effects, and chemosterilization for the target species. In animals, amitraz show signs of CNS depression or stimulation according to the dose levels.


Amitraz poisoning in children: Clin Toxicol ; Atropine is useful for treating hemodynamically unstable bradycardia. Amitraz toxicosis associated with ingestion of an acaricide collar in a dog. Since its discovery by Boots Co. Torsades de pointes in amitraz poisoning.

Prostaglandin synthesis inhibited by formamidine pesticides.

The amitraz- octopamine receptor interaction restrains these normal ;oisoning of the octopamine receptor. Effects of the pesticide amitraz and its metabolite BTS on insulin and glucagon secretion from the perfused rat pancreas: Amitraz is used as a pesticide.

Presence of coma, absence of light reflex, and respiratory failure are probably due to the ingestion of a greater amount of amitraz, which supports its dose-dependent effects on body systems. Amitraz – intoxication – morbidity – overdose – pesticide – poisoning – toxicity.