In the present investigation, an attempt was made to formulate the oral sustained release matrix tablets of Ambroxol HCl in order to improve. DEVELOPMENT OF STABLE AMBROXOL HYDROCHLORIDE SYRUP AND. COMPARITIVE EVALUATION WITH MARKETED SAMPLES” is a bonafide. Expert Opin Drug Metab Toxicol. Aug;4(8) doi: / Ambroxol in the 21st century: pharmacological and clinical update.

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Asthma is a complex disease in which numerous factors contribute to the characteristic features of the disease, persistent airway dysfunction including AHR and allergic airway inflammation The p values for significance were set to 0.

Find articles by Katsuyuki Takeda. Decreased levels of protein carbonyls were detected in BAL fluid following ambroxol treatment after challenge.

In other experiments, as illustrated in Fig.

Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation

The assumption was that the anti-oxidant effects of ambroxol were transient and decreased levels of protein carbonyls in BAL fluid were not observed 2 days after cessation of ambroxol treatment.

A second effect of the drug may lie in the anti-oxidant activity. Ambroxol or saline were administrated following OVA challenge.

National Center for Biotechnology InformationU. Taken together, ambroxol was effective in preventing AHR and airway inflammation through upregulation of Th1 cytokines and uurnal from oxidative stress in the airways.


Recent studies revealed that the epidermal growth factor receptor EGF-R appeared to be a convergent pathway for a number of mediator signals; EGF-R was upregulated in the airways of asthmatic patients 9. Airway hyperresponsiveness AHRlung cell composition and histology, and cytokine and protein carbonyl levels in bronchoalveolar lavage BAL fluid were determined.

Determination of airway responsiveness Airway responsiveness was assessed as changes in airway function after challenge with aerosolized methacholine MCh Sigma. Cochrane Database Syst Rev. Oxidative stress in allergic respiratory diseases.

Ambroxol in the 21st century: pharmacological and clinical update.

Ambroxol treatment in sham-sensitized mice showed no effect on cytokine levels or cell composition in BAL fluid or AHR. Malerba M, Ragnoli B. However, the underlying mechanisms whereby ambroxol exhibits anti-inflammatory effects in the airways such as in asthma remain to be defined. The animals were maintained on an ovalbumin OVA -free diet. Mice were anesthetized, tracheostomized, mechanically ventilated, and lung function was assessed as described jurnxl Aerosolized MCh was administered for 8 seconds with a tidal volume of 0.

Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation

Nurnal the Th2 cytokine basis of asthma. Excessive mucus production is a major component of many respiratory diseases, including bronchial asthma, chronic obstructive pulmonary disease COPDand cystic fibrosis 3. Local treatment with IL is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice.


To investigate the role of ambroxol as an anti-oxidant agent, we determined protein carbonyl levels in BAL fluid as an index of oxidative stress in the lung J Obstet Gynaecol Res. Effect of ambroxol on airway responses when administered prior to initiation of allergen challenge. Cellspecific modulation of surfactant proteins by ambroxol treatment. Ambroxol was administered either before the first OVA challenge or was begun after the last allergen challenge.

Ambroxol in the 21st century: pharmacological and clinical update.

Ambroxol has been in the clinic for many years, the drug is inexpensive and few adverse effects have been described. Effect of ambroxoo on airway responses when administered after completion of the allergen challenges. Among these factors, Th2 cells and related cytokines, IL-4, IL-5, and IL are thought to play a central role in the pathogenesis of the disease This may indicate that the anti-oxidant properties of ambroxol target airway function with little to no effect on airway inflammation.

The data for RL were continuously collected for up to 3 minutes and maximum values were taken. Ambroxol in the 21st century: