HYVET STUDY PDF

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Keywords: elderly, hypertension, HYVET, older adults, treatment In the pilot study, subjects aged over 80 years, with a sustained blood. Kardiol Pol. Jul;66(7); discussion [HYVET study – treatment for hypertension]. [Article in Polish]. Zalewska J(1). Author information. “In the main HYVET study, we aimed to resolve persistent areas of clinical uncertainty about the relative benefits and risks of antihypertensive.

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[HYVET study – treatment for hypertension].

Formal education was protective HR 0. The initial inclusion criteria demanded both systolic and diastolic hypertension SDH stuy systolic BP — mmHg; mean diastolic BP 90— mmHgoff treatment, during a 2 month run in period. Beckett NS, et al. Yet the authors of the meta-analysis noted that a single, randomized controlled trial demonstrating no benefit from anti-hypertensive therapy, in this cohort, would negate the hyve benefits seen across their meta-analysis [ 11 ].

HYVET also has a number of methodological issues, namely the protocol amendment which provided for the inclusion of subjects with ISH and the variable methods for measuring blood pressure.

The Hypertension in the Very Elderly Trial – latest data

Allowing for all fractures, regardless of whether they were incident, validated fractures or not, resulted in an adjusted HR of 0. As a result, it remains unclear whether such benefits persist or diminish over a longer time course and although the inclusion criteria allowed for the enrolment of patients aged between 80 and years, most were 80 to 85 years old mean age; Subjects were then randomized to gyvet of two treatment arms, the thiazide like diuretic, indapamide sustained release, 1.

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Mortality by race-sex and age. Author information Article notes Copyright and License information Disclaimer. Earlier this year, results from a 1 year open label active treatment extension studu HYVET were published.

Secondary outcomes included rates of fatal stroke, all-cause mortality, and CV events. Furthermore, a failure to routinely identify vertebral fractures and difficulties in data collection may be sources of error. This treatment regimen was also found to be associated with a large and significant reduction in heart failure, whilst proving particularly efficacious in the management of isolated systolic hypertension.

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Treatment of hypertension in the elderly. Stepwise treatment consisted of a diuretic indapamide sustained release 1. Equally, at the time of the second interim analysis July the relative risk of all stroke fatal and non-fatal amongst those receiving active treatment was 0.

Mancia G, Grassi G.

Reduction in mortality of persons with high blood pressure, including mild hypertension. This may reflect the relative physical well being of the trial population [ 24 ]. Main study findings A double-blind placebo-controlled trial with recruitment centres in 13 countries, HYVET prospectively analyzed data from older adults.

The New Shudy Journal of Medicine. Navigation menu Personal tools Create account Log in. All authors have completed the Unified Competing Interest form at http: It is possible that the difference in stroke rates would have reached statistical significance had the trial not been stopped early. Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET.

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However there was a non-significant rise in all cause mortality RHR 1. Effects of treatment on morbidity in hypertension. hvyet

Some have interpreted HYVET as a negative study, since the P value for the primary outcome of stroke did not reach statistical significance. This review provides an overview of the Hypertension in the Very Elderly Trial whilst also discursively evaluating the latest data.

[HYVET study – treatment for hypertension].

Five-year findings of the Hypertension Detection and Follow-up Program: More recently, additional data from this cohort has been published suggesting that appropriate anti-hypertensive therapy may lead to a reduction in incident cognitive impairment and fractures, whilst a 1 year open label extension of the main study confirmed many of the stusy trial findings.

There were also significant reductions in rates of other secondary outcomes including fatal stroke, HF, and CV events. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension.

Published online Aug Furthermore, standing and stidy BPs post-treatment were equivalent, suggesting that antihypertensive therapy was not associated with orthostatic hypotension [ 13 ].

Br J Clin Pharmacol.

Conflict of interest statement All authors have completed the Unified Competing Interest form at http: In fact, serious adverse events SAEs were sutdy post-randomization in the placebo group.