Hydrotropic Solubilization. Priyanka Arjaria1, Manoj Goyal2, Suman Jain3. 1Shri Ram College of pharmacy,Banmore,Morena, India, 2IPS College of pharmacy. Purpose. This study examines the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system. The most commonly proposed mechanism. On the other hand, planarity of the hydrophobic part has been emphasized as an important factor in the mechanism of hydrotropic solubilization. Solute consists.

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View at Google Scholar Y. Pharma Science Monitor ; 4 3: Because of their low aqueous solubility and high permeability, dissolution from delivery systems forms the rate limiting step in their absorption and systemic bioavailability [ 23 ].

Hence it is necessary to increase the solubility of drug that may further increase bioavailability and also results in solubilizatoon of dose.

Intermediate precision study expresses variation within laboratory conditions in different days. The use of hydrotropy to give fast release of poorly water-soluble drugs from the suppositories.

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The pH dependent solubility of Lumefantrine in different phosphate buffers ranging from pH 1. The Controller of Publication, Delhi, The linear standard curve of Lumefantrine soluilization the graph equation was depicted in Fig. From the above solution 1, 2, 3, 4, 5 and 6 ml was taken and diluted upto 10ml with 0.

In intra- and interday precision and intersubject variation study, coefficient of variation was not more than 1. Once the saturated solution is prepared its analysis is carried out to check the solubility. Use of the solubility characteristics in bioavailability, pharmacological action and solubility enhancement of hydgotropic poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists.

International Journal of Pharmaceutical and Clinical Science ; 2 1: It can be concluded that the concept of hydrotropic solubilization technique is novel, safe, eco-friendly and economic for enhancing bioavailability of poorly water-soluble drugs. Here artemether is short acting where as lumefantrine is long acting anti malarial drug. Physical Pharmacy, New Delhi, B. For determination of interference of hydrotropic agents in the spectrophotometric estimation of the standard solutions of drugs were determined in distilled water alone and in the presence of the maximum concentration of the hydrotropic agent employed for spectrophotometric analysis.


Hydrotropic solubilization of poorly water-soluble drugs.

Ltd,4, Select your language of interest to view the total content in your interested language. A saturated solution is one in which the solute is in equilibrium with the solvent[]. All Published work is licensed under a Creative Commons Attribution 4. These include Potassium acetate 6.


Hydrotropes such as sodium benzoate, sodium salicylate, niacinamide, sodium hydroxide, sodium citrate, PEGpolyvinyl alcohol, and urea have been employed to enhance the aqueous solubility of poorly water-soluble hydrotropix [ 3 ]. Digest Journal of Nanomaterials and Biostructures ; 5 1: Quantitative analysis of theophylline bulk sample using sodium salicylate hydrotrope.

The study revealed that estimations of lornoxicam can be done within 24 hours without any detrimental effect on drug stability as no precipitation was observed. International Journal of Pharmaceutics ; Preparation of hydrotropic solid dispersions of poorly water-soluble drugs precluding the use of organic solvents.

Common products containing a hydrotropes include laundry detergents, surface cleaners, solubilizayion detergents, liquid soaps, shampoos and conditioners.

Solubility enhancement of theophylline drug using different solubilization techniques. Solubility Studies using Hydrotropes: This method could preclude the use of costly solvents in analysis.

A simple spectrophotometric estimation of Ketoprofen in tablets using mixed hydrotropy. The process of solubilisation involves the breaking of inter-ionic or intermolecular bonds in the solute, the separation of the molecules of the solvent to provide space in the solvent for the solute, interaction between the solvent and the solute molecule or ion. The authors are thankful for Gokula Education Foundation for providing necessary facilities to carry out the research work.


A novel application of hydrotropic solubilizationindevelopment and validation of spectrophotometric method forsimultaneous estimation of paracetamol and diclofenac sodium in solid dosage form International Journal of Pharma and Bio Sciences ; 1 3: By using this site, you agree to the Terms of Use and Privacy Policy.

Application of mixed- hydrotropy to develop injection dosage forms of poorly water-soluble drugs. Views Read Edit View history.

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An excess quantity of drug was added to a series of stoppered conical flasks containing 10 ml of hydrotropic solutions until saturated solution was obtained.

Hydrotropes are in use industrially and commercially in cleaning and personal care product formulations to allow more concentrated formulations of surfactants. Indian Pharmacist ; 6: All other chemicals and solvents used were of analytical grade. Such a solution is called saturated. Enhancement of water solubility of felodipine by preparing solid dispersion using poly-ethylene glycol and poly-vinyl alcohol.

There was more than a 18? The anionic group is involved in bringing about high aqueous solubility, which is a prerequisite for a hydrotropic substance.

Hydrotropes or hydrotropic agents are molecules having planar hydrotropic structure brought into solution by a polar group. Hydrochlorothiazide shows maximum absorbance at nm. Solubility of Lumefantine in water was 0.

Quantitative estimations of poorly watersoluble drugs by UV-Visible spectrophotometric analysis precluding the use of organic solvents.