FLUVASTATIN PACKAGE INSERT PDF
Fluvastatin, a fully synthetic cholesterol-lowering agent, is a The parent drug is targeted to the liver and no active metabolites are present. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Lescol (fluvastatin). PACKAGE LEAFLET: INFORMATION FOR THE USER. Fluvastatin 20 mg and 40 mg Hard Capsules. (fluvastatin). Read all of this leaflet carefully before you.
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For most patients, myopathy symptoms induced by statin therapy resolve relatively quickly; however, the results of the PRIMO study showed that it may take up to 2 months for resolution of symptoms. Novartis Pharmaceuticals Corporation; July Concurrent therapy with amiodarone or verapamil: Therefore, bile acid resins inserr be the optimal choice in those patients without triglyceride abnormalities who cannot tolerate statin therapy.
Decreases in serum ubiquinone do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans.
Crestor rosuvastatin package insert. One proposed mechanism suggests that decreased cholesterol concentrations secondary to statin therapy may result in alterations fluvwstatin myocyte membrane cholesterol. Reference s National Institutes of Health, U.
Pfizer, Inc; January Lipitor atorvastatin package insert. Statins are a class of medications widely used for primary and secondary prevention of cardiovascular events. Randomized, controlled trials report about a 1. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease Study of Heart and Renal Protection: Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Risk factors and drug interactions predisposing fluvaststin statin-induced myopathy.
Calan verapamil package insert. Patients requiring less aggressive treatment or predisposed to myopathy including inssert of Asian descent: After 2 weeks, may be increased by mg once daily; dosing range: Novartis Pharmaceuticals Corporation; October An alternative option is the lfuvastatin of nonstatin lipid-lowering agents in place of statin therapy.
Cyclosporine and fluconazole are among the many agents that potentiate myopathy risk. Current overview of statin-induced myopathy. Pravachol pravastatin package insert. Simvastatin with or without ezetimibe in familial hypercholesterolemia. Livalo pitavastatin package insert. Additionally, the role of vitamin D has been somewhat controversial, as low levels are associated with both myalgia and poor muscle function.
Effects of coenzyme Q10 on statin-induced myopathy: Pravachol pravastatin package insert. The role of CoQ10 in inserg myopathy: Adjustments should be made at intervals of weeks.
When a statin is suspected as the cause of mild-to-moderate symptoms, temporary withdrawal is recommended. Recommendations ineert management of clinically significant drug-drug interactions with statins and select agents used in patients with cardiovascular disease: Statin-associated myopathy may be dose related. Pacerone amiodarone package insert.
A second proposed mechanism involves depletion of isoprenoids that control myofiber apoptosis, and a third mechanism suggests that a depletion of ubiquinone or coenzyme Q10 CoQ 10 may account for the potential myotoxicity of statins. It is proposed that insrt cholesterol plays a key role in cell membrane fluidity, lowering cholesterol with a statin may possibly disturb the integrity of the myocyte and lead to membrane destabilization.
Both dihydropyridine amlodipine and paclage CCBs diltiazem, verapamil have been shown to have meaningful drug interactions with statins.
fluvastatin (LESCOL, LESCOL XL)
Bristol-Myers Squibb Company; July Novartis Pharmaceuticals Corp; August First, owing to a higher likelihood of symptoms, the clinician may choose to avoid the most lipophilic statins inserg and simvastatin in favor of more hydrophilic statins fluvastatin, pravastatin, and rosuvastatin.
The precise mechanisms underlying statin-associated myopathy are not well understood; however, theories do exist.
Based on current levels and individualized goals, statins alone or in combination with other agents should be initiated based on expected LDL-C— or non—HDL-C—lowering ability. While myopathy caused by statins can be mild and can be reversed when insery medication is discontinued, it may present as rhabdomyolysis or severe muscle damage.
Studies evaluating vitamin D supplementation as prevention have been limited in their packahe and require validation through a larger randomized, double-blind, placebo-controlled trial. Zocor simvastatin package insert. How to balance cardiorenometabolic benefits and risks of statins.
These studies have shown that in patients with a prior statin intolerance, the use of another statin is both well tolerated and efficacious. Disclaimer The authors make no claims of the accuracy of the fluvvastatin contained herein; and these suggested doses are not a substitute for clinical judgment.
Alternatives with a lower potential to induce myopathy have been explored, including fluvashatin use of fluvastatin extended release, low-dose rosuvastatin, every-other-day dosing of atorvastatin or rosuvastatin, and twice weekly rosuvastatin, though these regimens are not approved by the FDA.
Valeant Pharmaceuticals; November